LPMT | Biophysics Group

High Force Magnetic Tweezer Setup

Advanced experimental setup of the high force magnetic tweezer device.

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  • Rotation stage

    Multi Directional
    Force Application

    A new developed rotational device
    enables multidirectional tweezer
    measurements at high forces.


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  • High Force Magnetic Tweezer

    High Force Magnetic
    Tweezer Setup

    Advanced experimental
    setup of the high force
    magnetic tweezer device.


    Read more
  • Desminopathy

    Biomechanical Characterization of
    Desminopathy in Human Myoblasts

    Expression of mutant desmin leads to increased
    mechanical stiffness, resulting in excessive
    stress and increased mechanical vulnerability
    of human muscle cells.


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  • Cell stretcher

    Cell Stretcher

    High performance cell stretching
    device to inverstigate cell response
    to external stress.

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  • Cell Plasticity

    Cytoskeletal Plasticity

    Flourescent imaging during force
    applicaiton to investigate cytoskeletal
    dynamics.


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  • Cell Migration

    Cell Migragtion Behaviour

    In order to investigate
    the influence of different proteins on the
    migration speed and behaviour of cells,
    we use an automatic cell tracker.


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  • Traction Forces Plectin

    Contribution of Plectin to
    Mechanical Properties

    We investigated to influence
    of the cytoskeletal linker protein
    plectin on the mechanical
    properties of different cell types.


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Dipl. Phys.

Navid Bonakdar

PhD candidate
Center of Medical Physics and Technology
(Fabry Lab)

Navid Bonakdar

Welcome to Cellmechanics

In my work I am focused on cell mechanics, especially the improvement and development of techniques to investigate biological cell functions. Mostly I am interested in cytoskeletal mechanics and in binding dynamics of cell adhesion to proteins.

Featured Methods
High force Magnetic Tweezer Device

Magnetic Tweezer

High force magnetic tweezer device

To verify the mechanical properties of the cytoskeleton of cells a high force magnetic tweezer device is used. Smal magnetic particles of 5µm diameter are bound via focal adhesion complex to the actin cytoskeleton. A precise magnet applies forces of up to more than 200nN to either easure the stiffness of the cell or the adhesion strength.

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Cell Stretcher

Stress Application

Cell stretcher

Application of external stress to cells leads to alterations in their probabilities. Like in physiological environment cells are permanently exposed to deformations. With the cell stretcher this influence can be investigated with the use of flourescent chemicals the viability of cells due to that stress can be visualized.

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Traction Force Microscopy

Force Reonstruction

Traction force microscopy

Cells can sense and also generate stress. By contracting their cytoskeleton they are able to generate forces to their underground where they are connected through their focal adhesion complex. This method makes it possible to measure this contractile forces by using gels which are deformed by the cells.

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Cell Migration

Microscopy

Live cell imaging

Cell movement is very important issue and can be investigated through live cell imaging. With this method any cell line can be observed over several days under physiological conditions. Using recognitional software it is for example possible to track their movement and thus their speed.

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